Panel

panel somatic mutation analysis (MSH2, MSH6)

Turnaround time
3 weeks
Performing laboratory
Radboudumc
€ 763

panel somatic mutation analysis (MSH2, MSH6)



€ 763

panel somatic mutation analysis (MSH2, MSH6)

This test is available for the following conditions:

  • Conditions > Oncogenetics > Lynch syndrome (HNPCC)

Turnaround time
3 weeks

Method

  • Sequence analysis of all coding exons and flanking intron-exon boundaries
Remarks
This test is developed for the detection of somatic mutations in MMR-deficient tumors in which no germline mutation could be detected.

Performing laboratory: Radboudumc
Authorized material(s): EDTA blood, FFPE, Isolated DNA




€ 763
Gene

MLH1 - Lynch syndrome

Turnaround time
Complete analysis: 8 weeks / Targeted analysis: 4 weeks
Performing laboratory
Radboudumc
€ 739

MLH1 - Lynch syndrome



€ 739

MLH1 - Lynch syndrome

This test is available for the following conditions:

  • Conditions > Oncogenetics > Lynch syndrome (HNPCC)

This product is also part of the following panels:

** % of the coding region of this gene has a coverage of >20x. (Without % information : This is a non-coding gene for which coverage statistics could not be determined)

Turnaround time
Complete analysis: 8 weeks / Targeted analysis: 4 weeks

Method

  • Sequence analysis of all coding exons and flanking intron-exon boundaries
  • Deletion/duplication analysis (MLPA)
Remarks
No MLPA is performed on DNA isolated from FFPE material. This results in a modest remaining risk.

OMIM: 120436
Performing laboratory: Radboudumc
Authorized material(s): EDTA blood, FFPE, Isolated DNA




€ 739
Gene

MLH1 - somatic mismatch repair deficiency (somatic hypermethylation)

Turnaround time
Complete analysis: 8 weeks / Targeted analysis: 4 weeks
Performing laboratory
Radboudumc
€ 495

MLH1 - somatic mismatch repair deficiency (somatic hypermethylation)



€ 495

MLH1 - somatic mismatch repair deficiency (somatic hypermethylation)

This test is available for the following conditions:

  • Conditions > Oncogenetics > Lynch syndrome (HNPCC)

This product is also part of the following panels:

** % of the coding region of this gene has a coverage of >20x. (Without % information : This is a non-coding gene for which coverage statistics could not be determined)

Turnaround time
Complete analysis: 8 weeks / Targeted analysis: 4 weeks

Method

  • Methylation analysis

OMIM: 120436
Performing laboratory: Radboudumc
Authorized material(s): FFPE




€ 495
Gene

MLH1 - somatic mutation-analysis

Turnaround time
Complete analysis: 8 weeks / Targeted analysis: 4 weeks
Performing laboratory
Radboudumc
€ 871

MLH1 - somatic mutation-analysis



€ 871

MLH1 - somatic mutation-analysis

This test is available for the following conditions:

  • Conditions > Oncogenetics > Lynch syndrome (HNPCC)

This product is also part of the following panels:

** % of the coding region of this gene has a coverage of >20x. (Without % information : This is a non-coding gene for which coverage statistics could not be determined)

Turnaround time
Complete analysis: 8 weeks / Targeted analysis: 4 weeks

Method

  • Sequence analysis of all coding exons and flanking intron-exon boundaries
Remarks
Normal and tumor tissue is required. DNA from blood is recommended.

OMIM: 120436
Performing laboratory: Radboudumc
Authorized material(s): FFPE




€ 871
Gene

MSH2 - Lynch syndrome

Turnaround time
Complete analysis: 8 weeks / Targeted analysis: 4 weeks
Performing laboratory
Radboudumc
€ 723

MSH2 - Lynch syndrome



€ 723

MSH2 - Lynch syndrome

This test is available for the following conditions:

  • Conditions > Oncogenetics > Lynch syndrome (HNPCC)

This product is also part of the following panels:

** % of the coding region of this gene has a coverage of >20x. (Without % information : This is a non-coding gene for which coverage statistics could not be determined)

Turnaround time
Complete analysis: 8 weeks / Targeted analysis: 4 weeks

Method

  • Sequence analysis of all coding exons and flanking intron-exon boundaries
  • Deletion/duplication analysis (MLPA)
Remarks
MLPA analysis cannot be performed on DNA isolated from FFPE material. This results in a modest remaining risk.

OMIM: 609309
Performing laboratory: Radboudumc
Authorized material(s): EDTA blood, FFPE, Isolated DNA




€ 723
Gene

MSH6 - Lynch syndrome

Turnaround time
Complete analysis: 8 weeks / Targeted analysis: 4 weeks
Performing laboratory
Radboudumc
€ 707

MSH6 - Lynch syndrome



€ 707

MSH6 - Lynch syndrome

This test is available for the following conditions:

  • Conditions > Oncogenetics > Lynch syndrome (HNPCC)

This product is also part of the following panels:

** % of the coding region of this gene has a coverage of >20x. (Without % information : This is a non-coding gene for which coverage statistics could not be determined)

Turnaround time
Complete analysis: 8 weeks / Targeted analysis: 4 weeks

Method

  • Sequence analysis of all coding exons and flanking intron-exon boundaries
  • Deletion/duplication analysis (MLPA)

OMIM: 600678
Performing laboratory: Radboudumc
Authorized material(s): EDTA blood, Isolated DNA, Buccal mucous membrane




€ 707
Gene

PMS2 - Lynch syndrome

Turnaround time
Complete analysis: 8 weeks / Targeted analysis: 4 weeks
Performing laboratory
Radboudumc
€ 772

PMS2 - Lynch syndrome



€ 772

PMS2 - Lynch syndrome

This test is available for the following conditions:

  • Conditions > Oncogenetics > Lynch syndrome (HNPCC)

This product is also part of the following panels:

** % of the coding region of this gene has a coverage of >20x. (Without % information : This is a non-coding gene for which coverage statistics could not be determined)

Turnaround time
Complete analysis: 8 weeks / Targeted analysis: 4 weeks

Method

  • Sequence analysis of all coding exons and flanking intron-exon boundaries
  • Deletion/duplication analysis (MLPA)

OMIM: 600259
Performing laboratory: Radboudumc
Authorized material(s): EDTA blood, Isolated DNA, Buccal mucous membrane




€ 772