Panel

panel somatic mutation analysis (MSH2, MSH6)

Turnaround time
3 weeks
Performing laboratory
Radboudumc
€ 1271

panel somatic mutation analysis (MSH2, MSH6)



€ 1271

panel somatic mutation analysis (MSH2, MSH6)

This test is available for the following conditions:

  • Conditions > Oncogenetics > Lynch syndrome (HNPCC)

Turnaround time
3 weeks

Method

  • Sequence analysis of all coding exons and flanking intron-exon boundaries
Remarks
This test is developed for the detection of somatic mutations in MMR-deficient tumors in which no germline mutation could be detected.

Performing laboratory: Radboudumc
Authorized material(s): EDTA blood, FFPE, Isolated DNA




€ 1271
Gene

MLH1 - Lynch syndrome

Turnaround time
Complete analysis: 8 weeks / Targeted analysis: 4 weeks
Performing laboratory
Radboudumc
€ 1114

MLH1 - Lynch syndrome



€ 1114

MLH1 - Lynch syndrome

This test is available for the following conditions:

  • Conditions > Oncogenetics > Lynch syndrome (HNPCC)

This product is also part of the following panels:

** % of the coding region of this gene has a coverage of >20x. (Without % information : This is a non-coding gene for which coverage statistics could not be determined)

Turnaround time
Complete analysis: 8 weeks / Targeted analysis: 4 weeks

Method

  • Sequence analysis of all coding exons and flanking intron-exon boundaries
  • Deletion/duplication analysis (MLPA)
Remarks
No MLPA is performed on DNA isolated from FFPE material. This results in a modest remaining risk.

OMIM: 120436
Performing laboratory: Radboudumc
Authorized material(s): EDTA blood, FFPE, Isolated DNA




€ 1114
Gene

MLH1 - somatic mismatch repair deficiency (somatic hypermethylation)

Turnaround time
Complete analysis: 8 weeks / Targeted analysis: 4 weeks
Performing laboratory
Radboudumc
€ 781

MLH1 - somatic mismatch repair deficiency (somatic hypermethylation)



€ 781

MLH1 - somatic mismatch repair deficiency (somatic hypermethylation)

This test is available for the following conditions:

  • Conditions > Oncogenetics > Lynch syndrome (HNPCC)

This product is also part of the following panels:

** % of the coding region of this gene has a coverage of >20x. (Without % information : This is a non-coding gene for which coverage statistics could not be determined)

Turnaround time
Complete analysis: 8 weeks / Targeted analysis: 4 weeks

Method

  • Methylation analysis

OMIM: 120436
Performing laboratory: Radboudumc
Authorized material(s): FFPE




€ 781
Gene

MLH1 - somatic mutation-analysis

Turnaround time
Complete analysis: 8 weeks / Targeted analysis: 4 weeks
Performing laboratory
Radboudumc
€ 1294

MLH1 - somatic mutation-analysis



€ 1294

MLH1 - somatic mutation-analysis

This test is available for the following conditions:

  • Conditions > Oncogenetics > Lynch syndrome (HNPCC)

This product is also part of the following panels:

** % of the coding region of this gene has a coverage of >20x. (Without % information : This is a non-coding gene for which coverage statistics could not be determined)

Turnaround time
Complete analysis: 8 weeks / Targeted analysis: 4 weeks

Method

  • Sequence analysis of all coding exons and flanking intron-exon boundaries
Remarks
Normal and tumor tissue is required. DNA from blood is recommended.

OMIM: 120436
Performing laboratory: Radboudumc
Authorized material(s): FFPE




€ 1294
Gene

MSH2 - Lynch syndrome

Turnaround time
Complete analysis: 8 weeks / Targeted analysis: 4 weeks
Performing laboratory
Radboudumc
€ 1092

MSH2 - Lynch syndrome



€ 1092

MSH2 - Lynch syndrome

This test is available for the following conditions:

  • Conditions > Oncogenetics > Lynch syndrome (HNPCC)

This product is also part of the following panels:

** % of the coding region of this gene has a coverage of >20x. (Without % information : This is a non-coding gene for which coverage statistics could not be determined)

Turnaround time
Complete analysis: 8 weeks / Targeted analysis: 4 weeks

Method

  • Sequence analysis of all coding exons and flanking intron-exon boundaries
  • Deletion/duplication analysis (MLPA)
Remarks
MLPA analysis cannot be performed on DNA isolated from FFPE material. This results in a modest remaining risk.

OMIM: 609309
Performing laboratory: Radboudumc
Authorized material(s): EDTA blood, FFPE, Isolated DNA




€ 1092
Gene

MSH6 - Lynch syndrome

Turnaround time
Complete analysis: 8 weeks / Targeted analysis: 4 weeks
Performing laboratory
Radboudumc
€ 1070

MSH6 - Lynch syndrome



€ 1070

MSH6 - Lynch syndrome

This test is available for the following conditions:

  • Conditions > Oncogenetics > Lynch syndrome (HNPCC)

This product is also part of the following panels:

** % of the coding region of this gene has a coverage of >20x. (Without % information : This is a non-coding gene for which coverage statistics could not be determined)

Turnaround time
Complete analysis: 8 weeks / Targeted analysis: 4 weeks

Method

  • Sequence analysis of all coding exons and flanking intron-exon boundaries
  • Deletion/duplication analysis (MLPA)

OMIM: 600678
Performing laboratory: Radboudumc
Authorized material(s): EDTA blood, Isolated DNA, Buccal mucous membrane




€ 1070
Gene

PMS2 - Lynch syndrome

Turnaround time
Complete analysis: 8 weeks / Targeted analysis: 4 weeks
Performing laboratory
Radboudumc
€ 1159

PMS2 - Lynch syndrome



€ 1159

PMS2 - Lynch syndrome

This test is available for the following conditions:

  • Conditions > Oncogenetics > Lynch syndrome (HNPCC)

This product is also part of the following panels:

** % of the coding region of this gene has a coverage of >20x. (Without % information : This is a non-coding gene for which coverage statistics could not be determined)

Turnaround time
Complete analysis: 8 weeks / Targeted analysis: 4 weeks

Method

  • Sequence analysis of all coding exons and flanking intron-exon boundaries
  • Deletion/duplication analysis (MLPA)

OMIM: 600259
Performing laboratory: Radboudumc
Authorized material(s): EDTA blood, Isolated DNA, Buccal mucous membrane




€ 1159