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Complement mediated renal disease panel

This test is available for the following conditions:

Conditions > Complement-mediated diseases > Atypical Hemolytic Uremic Syndrome (aHUS)
Conditions > Complement-mediated diseases > C3-Glomerulonephritis
Conditions > Complement-mediated diseases > C3-Glomerulopathy
Conditions > Complement-mediated diseases > Complement-mediated kidney disease
Conditions > Complement-mediated diseases > Complement Nephropathy
Conditions > Complement-mediated diseases > Dense Deposit Disease (DDD)
Conditions > Complement-mediated diseases > Kidney Transplantation
Conditions > Complement-mediated diseases > Membranoproliferative Glomerulonephritis (MPGN)
Conditions > Complement-mediated diseases > S. Pneumoniae HUS
Conditions > Complement-mediated diseases > STEC-HUS
Conditions > Complement-mediated diseases > Thrombotic microangiopathy (TMA)

Turnaround time
Regular: 2-3 months / Rapid: 15 working days

Method

Exome analysis (WES or WGS data)

Panel version: DG-4.3.0

2025-10-04-DG-4-2-0

Performing laboratory: Radboudumc
Authorized material(s): EDTA blood (preferably), isolated DNA (only when EDTA blood is not an option)

Type of exome analysis

Gene panel analysis

Gene panel analysis and exome wide analysis - 1 report Panel analysis directly followed by an exome wide analysis (if the gene panel analysis does not reveal the genetic cause of the disorder)

Form of analysis

Single analysis of proband only (DNA parents for storage) - TAT: 2-3 months

Trio/de novo analysis of proband and both parents - TAT: 2-3 months

Single analysis of proband only - TAT: 2-3 months

Rapid Trio/de novo analysis of proband and both parents - TAT: <15 business days This test is designed for prenatal anomalies, newborn or early childhood (severe/life-threatening) conditions or conditions in need of gene specific treatment options.

Rapid Single analysis of proband only - TAT: <15 business days This test is designed for severe/life-threatening conditions or conditions in need of gene-specific treatment options AND when trio/de novo analysis is not an option or common practice.

€ 750

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