Sick sinus syndrome

Arrhythmia and cardiac conduction disorders panel¹

This test is available for the following conditions:

• Conditions > Cardiovascular > Long QT syndrome
• Conditions > Cardiovascular > Short QT syndrome
• Conditions > Cardiovascular > Sick sinus syndrome

Turnaround time
8 weeks

Method

• Exome analysis (WES or WGS data)

Remarks
This test is inclusive panelwide CNV analysis. Upon request a genomewide CNV analysis can be performed.

Panel version: DG 3.8.1
Performing laboratory: Maastricht UMC+
Authorized material(s): EDTA blood (preferably), isolated DNA (only when EDTA blood is not an option)

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Long QT syndrome panel¹

This test is available for the following conditions:

• Conditions > Cardiovascular > Long QT syndrome
• Conditions > Cardiovascular > Short QT syndrome
• Conditions > Cardiovascular > Sick sinus syndrome

Turnaround time
8 weeks

Method

• Exome analysis (WES or WGS data)

Remarks
This test is inclusive panelwide CNV analysis. Upon request a genomewide CNV analysis can be performed.

Panel version: DG 3.8.1
Performing laboratory: Maastricht UMC+
Authorized material(s): EDTA blood (preferably), isolated DNA (only when EDTA blood is not an option)

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panel Arrhythmia targeting (13 genes) - LQT, SQT, BrS, CPVT, SSS ¹

This test is available for the following conditions:

• Conditions > Cardiovascular > Arrhythmogenic right ventricular cardiomyopathy (ARVD)
• Conditions > Cardiovascular > Brugada syndrome
• Conditions > Cardiovascular > Long QT syndrome
• Conditions > Cardiovascular > Short QT syndrome
• Conditions > Cardiovascular > Sick sinus syndrome

Turnaround time
8 weeks

Method

• Sequence analysis of all coding exons and flanking intron-exon boundaries

Remarks
It includes sequencing of all coding regions of the following 13 genes: CACNA1C, CALM1, CASQ2, HCN4, KCNE1, KCNE2, KCNH2, KCNJ2, KCNQ1, LMNA, RYR2, SCN5A en TRDN.

Performing laboratory: Maastricht UMC+
Authorized material(s): FFPE

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panel sick sinus syndrome (SCN5A, HCN4) ¹

This test is available for the following conditions:

• Conditions > Cardiovascular > Sick sinus syndrome

Turnaround time
8 weeks

Method

• Sequence analysis of all coding exons and flanking intron-exon boundaries

Performing laboratory: Maastricht UMC+
Authorized material(s): EDTA blood, Isolated DNA

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SCN5A - Sick sinus syndrome ¹

This test is available for the following conditions:

• Conditions > Cardiovascular > Sick sinus syndrome

This product is also part of the following panels:

• Arrhythmia and cardiac conduction disorders panel¹
• Dilated cardiomyopathy panel¹
• Heart disorders panel¹
• Long QT syndrome panel¹
• Mendelian inherited disorders panel
• panel Arrhythmia targeting (13 genes) - LQT, SQT, BrS, CPVT, SSS ¹
• panel sick sinus syndrome (SCN5A, HCN4) ¹

Turnaround time
Complete analysis: 8 weeks / Targeted analysis: 4 weeks

Method

• Exome analysis (WES or WGS data)

Remarks
This test is inclusive panelwide CNV analysis.

OMIM: 600163
Performing laboratory: Maastricht UMC+
Authorized material(s): EDTA blood, Isolated DNA, Buccal mucous membrane

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