DNA-first hereditary breast cancer

This test is available for the following conditions:

  • Conditions > Oncogenetics > Breast and Ovary cancer, hereditary

Turnaround time
Urgent (2-3 weeks)

Method

  • Sequence analysis of all coding exons and flanking intron-exon boundaries
  • CNV analysis of all genes based on NGS
Remarks

Het aanvragen van dit panel is voorbehouden aan oncologisch specialisten die met hun centrum deelnemen aan het zorgvernieuwingstraject DNA First. Deze test bevat analyse van de volgende genen: BRCA1, BRCA2, PALB2, CHEK2, ATM, BRIP1, RAD51C, RAD51D, BARD1 en PTEN.

•    U en uw patiënt ontvangen beiden schriftelijk de uitslag van het DNA-onderzoek. 
•    Een klinisch genetisch zorgprofessional overlegt een niet-afwijkende uitslag met u, deze geeft advies met betrekking tot eventueel aanvullend onderzoek bij uw patiënt en controleadviezen voor familieleden. U en uw patiënt ontvangen hier schriftelijk verslag van.
•    Bij een afwijkende uitslag ontvangt uw patiënt een uitnodiging voor een gesprek op de afdeling klinische genetica, afhankelijk van uw affiliatie in het Radboudumc of MUMC+. De aanvraag geldt als verwijzing naar de afdeling klinische genetica.


Performing laboratory: Radboudumc & Maastricht UMC+
Authorized material(s): EDTA blood




€ 0

Panel

DNA-first hereditary breast cancer

Turnaround time
Urgent (2-3 weeks)
Performing laboratory
Radboudumc & Maastricht UMC+
€ 0

DNA-first hereditary breast cancer



€ 0

DNA-first hereditary breast cancer

This test is available for the following conditions:

  • Conditions > Oncogenetics > Breast and Ovary cancer, hereditary

Turnaround time
Urgent (2-3 weeks)

Method

  • Sequence analysis of all coding exons and flanking intron-exon boundaries
  • CNV analysis of all genes based on NGS

Performing laboratory: Radboudumc & Maastricht UMC+
Authorized material(s): EDTA blood




€ 0
Panel

panel Age-related Macular Degeneration (CFH, CFI, CFB, C3)

Turnaround time
8 weeks
Performing laboratory
Radboudumc
€ 1150

panel Age-related Macular Degeneration (CFH, CFI, CFB, C3)



€ 1150

panel Age-related Macular Degeneration (CFH, CFI, CFB, C3)

This test is available for the following conditions:

  • Conditions > Complement-mediated diseases > Age-related Macular Degeneration (AMD)

Turnaround time
8 weeks

Method

  • Sequence analysis of all coding exons and flanking intron-exon boundaries

Performing laboratory: Radboudumc
Authorized material(s): EDTA blood, Isolated DNA




€ 1150
Panel

panel Alport syndrome (COL4A3, COL4A4, COL4A5) ¹

Turnaround time
8 weeks
Performing laboratory
Maastricht UMC+
€ 520

panel Alport syndrome (COL4A3, COL4A4, COL4A5) ¹



€ 520

panel Alport syndrome (COL4A3, COL4A4, COL4A5) ¹

This test is available for the following conditions:

  • Conditions > Hearing impairment > Alport syndrome
  • Conditions > Renal / Nephrological > Alport syndrome

Turnaround time
8 weeks

Method

  • Sequence analysis of all coding exons and flanking intron-exon boundaries

Performing laboratory: Maastricht UMC+
Authorized material(s): EDTA blood, Isolated DNA




€ 520
Panel

panel Arrhythmia targeting (13 genes) - LQT, SQT, BrS, CPVT, SSS ¹

Turnaround time
8 weeks
Performing laboratory
Maastricht UMC+
€ 618

panel Arrhythmia targeting (13 genes) - LQT, SQT, BrS, CPVT, SSS ¹



€ 618

panel Arrhythmia targeting (13 genes) - LQT, SQT, BrS, CPVT, SSS ¹

This test is available for the following conditions:

  • Conditions > Cardiovascular > Arrhythmogenic right ventricular cardiomyopathy (ARVD)
  • Conditions > Cardiovascular > Brugada syndrome
  • Conditions > Cardiovascular > Long QT syndrome
  • Conditions > Cardiovascular > Short QT syndrome
  • Conditions > Cardiovascular > Sick sinus syndrome

Turnaround time
8 weeks

Method

  • Sequence analysis of all coding exons and flanking intron-exon boundaries
Remarks
It includes sequencing of all coding regions of the following 13 genes: CACNA1C, CALM1, CASQ2, HCN4, KCNE1, KCNE2, KCNH2, KCNJ2, KCNQ1, LMNA, RYR2, SCN5A en TRDN.

Performing laboratory: Maastricht UMC+
Authorized material(s): FFPE




€ 618
Panel

panel atypical HUS (CFH, CFI, CFB, C3, MCP (CD46), MLPA CFH operon)

Turnaround time
8 weeks
Performing laboratory
Radboudumc
€ 1500

panel atypical HUS (CFH, CFI, CFB, C3, MCP (CD46), MLPA CFH operon)



€ 1500

panel atypical HUS (CFH, CFI, CFB, C3, MCP (CD46), MLPA CFH operon)

This test is available for the following conditions:

  • Conditions > Complement-mediated diseases > Atypical Hemolytic Uremic Syndrome (aHUS)
  • Conditions > Renal / Nephrological > Atypical Hemolytic Uremic Syndrome (aHUS)

Turnaround time
8 weeks

Method

  • Sequence analysis of all coding exons and flanking intron-exon boundaries

Performing laboratory: Radboudumc
Authorized material(s): EDTA blood, Isolated DNA




€ 1500
Panel

panel atypical HUS (CFHR1, CFHR2, CFHR3, CFHR4, CFHR5, THBD, DGKE, CFP, C2))

Turnaround time
8 weeks
Performing laboratory
Radboudumc
€ 1150

panel atypical HUS (CFHR1, CFHR2, CFHR3, CFHR4, CFHR5, THBD, DGKE, CFP, C2))



€ 1150

panel atypical HUS (CFHR1, CFHR2, CFHR3, CFHR4, CFHR5, THBD, DGKE, CFP, C2))

This test is available for the following conditions:

  • Conditions > Complement-mediated diseases > Atypical Hemolytic Uremic Syndrome (aHUS)
  • Conditions > Renal / Nephrological > Atypical Hemolytic Uremic Syndrome (aHUS)

Turnaround time
8 weeks

Method

  • Sequence analysis of all coding exons and flanking intron-exon boundaries

Performing laboratory: Radboudumc
Authorized material(s): EDTA blood, Isolated DNA




€ 1150
Panel

panel Basal Laminar Drusen (CFH, CFI, CFB, C3)

Turnaround time
8 weeks
Performing laboratory
Radboudumc
€ 1150

panel Basal Laminar Drusen (CFH, CFI, CFB, C3)



€ 1150

panel Basal Laminar Drusen (CFH, CFI, CFB, C3)

This test is available for the following conditions:

  • Conditions > Complement-mediated diseases > Basal Laminar Drusen
  • Conditions > Vision impairment / blindness > Basal Laminar Drusen

Turnaround time
8 weeks

Method

  • Sequence analysis of all coding exons and flanking intron-exon boundaries

Performing laboratory: Radboudumc
Authorized material(s): EDTA blood, Isolated DNA




€ 1150
Panel

panel C3-Glomerulonephritis (CFH, CFI, CFB, C3, MCP (CD46), MLPA CFH operon, CFHR5)

Turnaround time
8 weeks
Performing laboratory
Radboudumc
€ 1500

panel C3-Glomerulonephritis (CFH, CFI, CFB, C3, MCP (CD46), MLPA CFH operon, CFHR5)



€ 1500

panel C3-Glomerulonephritis (CFH, CFI, CFB, C3, MCP (CD46), MLPA CFH operon, CFHR5)

This test is available for the following conditions:

  • Conditions > Complement-mediated diseases > C3-Glomerulonephritis

Turnaround time
8 weeks

Method

  • Sequence analysis of all coding exons and flanking intron-exon boundaries

Performing laboratory: Radboudumc
Authorized material(s): EDTA blood, Isolated DNA




€ 1500
Panel

panel C3-Glomerulonephritis (CFHR1, CFHR2, CFHR3, CFHR4, THBD, DGKE, CFP, C2))

Turnaround time
8 weeks
Performing laboratory
Radboudumc
€ 1150

panel C3-Glomerulonephritis (CFHR1, CFHR2, CFHR3, CFHR4, THBD, DGKE, CFP, C2))



€ 1150

panel C3-Glomerulonephritis (CFHR1, CFHR2, CFHR3, CFHR4, THBD, DGKE, CFP, C2))

This test is available for the following conditions:

  • Conditions > Complement-mediated diseases > C3-Glomerulonephritis

Turnaround time
8 weeks

Method

  • Sequence analysis of all coding exons and flanking intron-exon boundaries

Performing laboratory: Radboudumc
Authorized material(s): EDTA blood, Isolated DNA




€ 1150
Panel

panel C3-Glomerulopathy (CFH, CFI, CFB, C3, MCP (CD46), MLPA CFH operon, CFHR5)

Turnaround time
8 weeks
Performing laboratory
Radboudumc
€ 1500

panel C3-Glomerulopathy (CFH, CFI, CFB, C3, MCP (CD46), MLPA CFH operon, CFHR5)



€ 1500

panel C3-Glomerulopathy (CFH, CFI, CFB, C3, MCP (CD46), MLPA CFH operon, CFHR5)

This test is available for the following conditions:

  • Conditions > Complement-mediated diseases > C3-Glomerulopathy

Turnaround time
8 weeks

Method

  • Sequence analysis of all coding exons and flanking intron-exon boundaries

Performing laboratory: Radboudumc
Authorized material(s): EDTA blood, Isolated DNA




€ 1500